Capture-C
http://www.ebi.ac.uk/efo/EFO_0007691
Term info
definition
Capture-C combines 3C and next-gen sequencing with oligonucleotide capture technology (OCT). OCT allows for hundreds of regions of interest to be isolated from a sample using specially designed RNA in solution. In Capture-C, a standard 3C experiment is performed; however the 3C ligated fragments are sonicated at the end. This allows the OCT protocol to enrich for the selected regions of interest. These enriched fragments are then sequenced. By performing an OCT, the cost and scale of the sequencing is greatly reduced, allowing many more samples to be processed, hence higher-throughput and improves the genomic resolution
term editor
Sirarat Sarntivijai