5C
http://www.ebi.ac.uk/efo/EFO_0007692
Term info
definition
5C stands for "Chromosome conformation capture carbon copy". It is an extension of the original 3C technique that studies 3-dimensional organisation and interaction of chromatin in a cell. It detects interactions among all loci by ligating universal primers to all fragments. As a result, the whole genome is covered, albeit at a relatively low coverage. The 5C technique overcomes the junctional problems at the intramolecular ligation step and is useful for constructing complex interactions of specific loci of interest.
term editor
Sirarat Sarntivijai