A single cell library construction process that involves labelling cells with sample-specific oligonucleotides, typically through antibody- or lipid-based reagents, such that cells from distinct samples can be pooled together for single-cell sequencing. This multiplexed approach increases throughput, eliminates batch effects, and enables detection of multiplets. [ https://orcid.org/0000-0002-3564-4813 http://www.ncbi.nlm.nih.gov/pubmed/30567574 ]