hematopoietic stem cell
http://purl.obolibrary.org/obo/CL_0000037
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. [ GOC:add http://www.ncbi.nlm.nih.gov/pubmed/19022770 GOC:dsd GOC:tfm http://en.wikipedia.org/wiki/Hematopoietic_stem_cell ]
Synonyms: blood forming stem cell, HSC, hemopoietic stem cell
Term info
- MESH:D006412
- BTO:0000725
- FMA:70337
- VHOG:0001485
- CALOHA:TS-0448
- FMA:86475
human_reference_atlas
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.
colony forming unit hematopoietic
cell
http://purl.obolibrary.org/obo/uberon.owl, http://purl.obolibrary.org/obo/cl.owl
Hemal stem cell, Hemopoietic stem cell
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- hematopoietic cell and capable of some hematopoietic progenitor cell differentiation and capable of some somatic stem cell division and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- hematopoietic cell and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse) and capable of some hematopoietic progenitor cell differentiation and capable of some somatic stem cell division
- hematopoietic precursor cell
- somatic stem cell
- progenitor cell
- lacks_plasma_membrane_part some CD4 molecule
- lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- lacks_plasma_membrane_part some CD2 molecule
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain
- lacks_plasma_membrane_part some CD4 molecule
- develops from some angioblastic mesenchymal cell
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD5
- lacks_plasma_membrane_part some lymphocyte antigen 6G
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain
- lacks_plasma_membrane_part some lymphocyte antigen 6G
- lacks_plasma_membrane_part some integrin alpha-M
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- lacks_plasma_membrane_part some CD3 epsilon
- lacks_plasma_membrane_part some CD3 epsilon
- lacks_plasma_membrane_part some CD2 molecule
- lacks_plasma_membrane_part some integrin alpha-M
- lacks_plasma_membrane_part some CD14 molecule
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD5
- lacks_plasma_membrane_part some CD14 molecule
- lacks_plasma_membrane_part some neural cell adhesion molecule 1
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some neural cell adhesion molecule 1
- capable of some hematopoietic progenitor cell differentiation
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1