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Kupffer cell

^ http://purl.obolibrary.org/obo/CL_0000091

A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. [ MESH:D007728 http://www.ncbi.nlm.nih.gov/pubmed/15771589 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/17105582 GOC:add http://openisbn.com/search.php?q=0517223651&isbn=1/ http://purl.obolibrary.org/obo/go/references/0000031 ]

Synonyms: von Kupffer cell, stellate cell of von Kupffer, littoral cell of hepatic sinusoid, macrophagocytus stellatus, liver macrophage, hepatic macrophage

Term info

database cross reference
  • FMA:14656
  • BTO:0000685
Subsets

human_reference_atlas

comment

Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606