JSON

keratinocyte

^ http://purl.obolibrary.org/obo/CL_0000312


An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. [ http://en.wikipedia.org/wiki/Keratinocyte http://www.ncbi.nlm.nih.gov/pubmed/15749908 http://www.ncbi.nlm.nih.gov/pubmed/19727116 GOC:dsd MESH:D015603 http://www.ncbi.nlm.nih.gov/pubmed/15582983 ]

Synonyms: malpighian cell, keratinized cell of epidermis

Term info

database cross reference
  • CALOHA:TS-0500
  • BTO:0000667
  • FMA:62879
Subsets

human_reference_atlas

comment

Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.

has alternative id

CL:0002185

prefLabel

Keratinized cell of epidermis

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606