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Langerhans cell

^ http://purl.obolibrary.org/obo/CL_0000453


Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. [ GOC:add GOC:amm http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2346585 http://purl.obolibrary.org/obo/go/references/0000031 http://openisbn.com/search.php?q=0781735149&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/17850486 ]

Synonyms: LC

Term info

database cross reference
  • MESH:D007801
  • FMA:63072
  • BTO:0000705
  • CALOHA:TS-2375
Subsets

human_reference_atlas

comment

Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.

prefLabel

Langerhans cell

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606