mucosal type mast cell
http://purl.obolibrary.org/obo/CL_0000485
Mast cell subtype that contains only the serine protease trypase in its granules. These cells are primarily found in mucosal tissue, such as intestinal mucosa and alveoli. They depend upon T-cells for development of phenotype. [ http://www.ncbi.nlm.nih.gov/pubmed/9354811 http://www.ncbi.nlm.nih.gov/pubmed/19923473 GOC:add GOC:dsd ]
Synonyms: T mast cells, MC(T), MCT
Term info
human_reference_atlas
They are CD88-negative. The cytoplasmic granules contain low levels of histamine and high levels of chondroitin sulfate (mouse) or major neutral proteases and tryptase (humans). Additionally, they can produce leukotrienes (LTC4), IL-5, IL-6, and low levels of IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype.
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- mast cell and part of some mucosa-associated lymphoid tissue and capable of some leukotriene production involved in inflammatory response