granulocyte monocyte progenitor cell
http://purl.obolibrary.org/obo/CL_0000557
A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. [ http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC548021 MESH:D055014 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/16647566 http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.copewithcytokines.de http://www.ncbi.nlm.nih.gov/pubmed/16551251 GOC:amm http://purl.obolibrary.org/obo/go/references/0000031 http://en.wikipedia.org/wiki/CFU-GM GOC:dsd http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2213186 ]
Synonyms: granulocyte/monocyte progenitor, colony forming unit granulocyte macrophage, CFU-GM, granulocyte/monocyte precursor, GMP, granulocyte-macrophage progenitor
Term info
human_reference_atlas
Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
CFU-C , Colony forming unit in culture
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- hematopoietic oligopotent progenitor cell and part of some bone marrow and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and capable of some macrophage differentiation and capable of some granulocyte differentiation and lacks_part some erythroid transcription factor and lacks_part some endothelial transcription factor GATA-2
- hematopoietic oligopotent progenitor cell and part of some bone marrow and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and lacks_part some erythroid transcription factor and lacks_part some endothelial transcription factor GATA-2 and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and capable of some macrophage differentiation and capable of some granulocyte differentiation
- bone marrow hematopoietic cell
- progenitor cell
- protein-containing material entity
- myeloid cell
- CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
- lacks_part some erythroid transcription factor
- capable of some granulocyte differentiation
- capable of some macrophage differentiation
- has part some transcription factor PU.1
- has plasma membrane part some interleukin-3 receptor class 2 alpha chain
- has part some CCAAT/enhancer-binding protein alpha
- lacks_part some endothelial transcription factor GATA-2
- lacks_part some endothelial transcription factor GATA-2
- lacks_part some erythroid transcription factor