neutrophilic metamyelocyte
http://purl.obolibrary.org/obo/CL_0000582
A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. [ http://www.cap.org GOC:add GOC:dsd GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/12560239 http://www.ncbi.nlm.nih.gov/pubmed/15514007 http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/10618520 ]
Synonyms: juvenile neutrophil
Term info
- FMA:84197
These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction.
Term relations
- immature neutrophil and has part some acidophilic cytoplasm and has part some reniform nucleus and has part some heterochromatin and has part some azurophil granule and has part some tertiary granule and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and has part some CCAAT/enhancer-binding protein epsilon and has part some neutrophil gelatinase-associated lipocalin and has part some lactotransferrin and has part some myeloperoxidase and lacks_plasma_membrane_part some fMet-Leu-Phe receptor and has plasma membrane part some integrin alpha-M and has plasma membrane part some alpha-(1,3)-fucosyltransferase 4 and has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III and has plasma membrane part some CD33 molecule and has plasma membrane part some signal transducer CD24 and has plasma membrane part some aminopeptidase N
- metamyelocyte
- immature neutrophil
- has part some transcription factor PU.1
- has plasma membrane part some aminopeptidase N
- has part some CCAAT/enhancer-binding protein alpha
- has part some acidophilic cytoplasm
- has part some heterochromatin
- has plasma membrane part some CD33 molecule
- develops from some neutrophilic myelocyte
- has part some reniform nucleus
- has plasma membrane part some alpha-(1,3)-fucosyltransferase 4
- lacks_plasma_membrane_part some fMet-Leu-Phe receptor
- has part some azurophil granule
- has part some myeloperoxidase
- has part some tertiary granule
- has part some neutrophil gelatinase-associated lipocalin
- has part some CCAAT/enhancer-binding protein epsilon
- has part some lactotransferrin
- has plasma membrane part some signal transducer CD24
- has plasma membrane part some low affinity immunoglobulin gamma Fc region receptor III