plasma cell
http://purl.obolibrary.org/obo/CL_0000786
A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. [ http://openisbn.com/search.php?q=0721601464&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/20951740 http://purl.obolibrary.org/obo/go/references/0000031 http://en.wikipedia.org/wiki/Plasma_cell http://www.ncbi.nlm.nih.gov/pubmed/20839338 http://www.ncbi.nlm.nih.gov/pubmed/19447676 GOC:add GOC:dsd http://openisbn.com/search.php?q=0781735149&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/20081059 ]
Synonyms: plasma B-cell, plasma B cell, plasmocyte, plasmacyte
Term info
- FMA:70574
- MESH:D010950
- BTO:0000392
human_reference_atlas
Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.
effector B cell, effector B-cell
Plasma cell
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- antibody secreting cell and has part some cartwheel heterochromatin and has part some Golgi apparatus and has plasma membrane part some syndecan-1 and lacks_plasma_membrane_part some immunoglobulin complex and lacks_plasma_membrane_part some MHC class II protein complex and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- antibody secreting cell and has part some cartwheel heterochromatin and has part some Golgi apparatus and lacks_plasma_membrane_part some immunoglobulin complex and lacks_plasma_membrane_part some MHC class II protein complex and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some syndecan-1
- antibody secreting cell
- protein-containing material entity
- develops from some plasmablast
- lacks_plasma_membrane_part some immunoglobulin complex
- lacks_plasma_membrane_part some MHC class II protein complex
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- lacks_plasma_membrane_part some MHC class II protein complex
- has part some cartwheel heterochromatin
- has part some Golgi apparatus
- lacks_plasma_membrane_part some immunoglobulin complex
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has plasma membrane part some syndecan-1