DN3 thymocyte
http://purl.obolibrary.org/obo/CL_0000807
A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. [ GOC:add http://purl.obolibrary.org/obo/go/references/0000031 http://openisbn.com/search.php?q=0781735149&isbn=1/ GOC:tfm ]
Synonyms: TN3 thymocyte, preT.DN3.Th, double negative 3, DN3 cell, TN3 cell, DN3 alpha-beta immature T-lymphocyte, DN3 immature T cell, DN3 alpha-beta immature T-cell, DN3 alpha-beta immature T lymphocyte
Term info
There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
early cortical thymocyte
Term relations
- thymocyte and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some CD44 molecule and lacks_plasma_membrane_part some T cell receptor co-receptor CD8 and has plasma membrane part some pre-T cell receptor complex and has plasma membrane part some interleukin-2 receptor subunit alpha