DN4 thymocyte
http://purl.obolibrary.org/obo/CL_0000808
A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. [ GOC:add GOC:tfm http://purl.obolibrary.org/obo/go/references/0000031 http://openisbn.com/search.php?q=0781735149&isbn=1/ ]
Synonyms: DN4 immature T cell, double negative 4, DN4 immature T-cell, DN4 alpha-beta immature T lymphocyte, DN4 alpha-beta immature T-lymphocyte, DN4 cell, T.DN4.th
Term info
Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
early cortical thymocyte
Term relations
- thymocyte and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some CD44 molecule and lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha and lacks_plasma_membrane_part some T cell receptor co-receptor CD8 and has plasma membrane part some pre-T cell receptor complex