pro-B cell
http://purl.obolibrary.org/obo/CL_0000826
A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. [ GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/16551251 http://www.ncbi.nlm.nih.gov/pubmed/18432934 http://openisbn.com/search.php?q=0781735149&isbn=1/ GOC:add http://www.ncbi.nlm.nih.gov/pubmed/12633665 ]
Synonyms: pro-B lymphocyte, progenitor B lymphocyte, pro-B-lymphocyte, pro-B-cell, progenitor B cell, progenitor B-lymphocyte, progenitor B-cell
Term info
- BTO:0003104
human_reference_atlas
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
pre-B cell (Philadelphia nomenclature)
pre-pro B cell
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- lymphoid lineage restricted progenitor cell and has part some paired box protein PAX-5 and has part some DNA nucleotidylexotransferase and participates_in some immunoglobulin V(D)J recombination