marginal zone B cell of spleen
http://purl.obolibrary.org/obo/CL_0000845
A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high. [ GOC:add GOC:dsd http://en.wikipedia.org/wiki/Marginal-zone_B_cell http://www.ncbi.nlm.nih.gov/pubmed/10933592 http://openisbn.com/search.php?q=0781735149&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/20933013 ]
Synonyms: marginal zone of spleen B cell, B cell of marginal zone of spleen
Term info
human_reference_atlas
MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.
marginal zone B-cell, MZ B lymphocyte, MZ B cell, MZ B-lymphocyte, marginal zone B lymphocyte, marginal zone B-lymphocyte, marginal zone B cell, MZ B-cell
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- mature B cell and part of some marginal zone of spleen and lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor and lacks_plasma_membrane_part some complement component C1q receptor and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some complement receptor type 2 and capable of some defense response to bacterium and has high plasma membrane amount some IgM immunoglobulin complex
- mature B cell and part of some marginal zone of spleen and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some complement receptor type 2 and capable of some defense response to bacterium and has high plasma membrane amount some IgM immunoglobulin complex and lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor and lacks_plasma_membrane_part some complement component C1q receptor
- splenocyte
- mature B cell
- lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor
- has high plasma membrane amount some IgM immunoglobulin complex
- has plasma membrane part some complement receptor type 2
- capable of some defense response to bacterium
- lacks_plasma_membrane_part some complement component C1q receptor
- has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- lacks_plasma_membrane_part some complement component C1q receptor
- part of some marginal zone of spleen
- lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor