inflammatory macrophage
http://purl.obolibrary.org/obo/CL_0000863
An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity. [ http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/19132917 GOC:ana ]
Synonyms: classically activated macrophage
Term info
Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).
M1 macrophage
Term relations
- elicited macrophage and capable of some interleukin-1 beta production and capable of some interleukin-6 production and capable of some tumor necrosis factor production and capable of some superoxide anion generation and capable of some defense response to bacterium and capable of some nitric-oxide synthase biosynthetic process
- elicited macrophage
- capable of some interleukin-1 beta production
- capable of some superoxide anion generation
- capable of some nitric-oxide synthase biosynthetic process
- capable of some interleukin-6 production
- capable of some tumor necrosis factor production
- capable of some defense response to bacterium