naive thymus-derived CD4-positive, alpha-beta T cell
http://purl.obolibrary.org/obo/CL_0000895
An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low. [ http://www.immgen.org/index_content.html http://www.ncbi.nlm.nih.gov/pubmed/19100699 http://www.ncbi.nlm.nih.gov/pubmed/22343568 http://purl.obolibrary.org/obo/go/references/0000031 GOC:add GOC:tfm ]
Synonyms: naive thymus-derived CD4-positive, alpha-beta T lymphocyte, naive thymus-derived CD4-positive, alpha-beta T-lymphocyte, naive thymus-derived CD4-positive, alpha-beta T-cell, Th0, T.4Nve.Sp
Term info
human_reference_atlas
These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells.
naive CD4+ T cell
http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- CD4-positive, alpha-beta T cell and lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA and has plasma membrane part some C-C chemokine receptor type 7 and has plasma membrane part some interleukin-7 receptor subunit alpha and has high plasma membrane amount some L-selectin and has low plasma membrane amount some CD44 molecule
- naive T cell
- CD4-positive, alpha-beta T cell
- lacks_plasma_membrane_part some interleukin-2 receptor subunit alpha
- develops from some mature CD4 single-positive thymocyte