pre-B-I cell

http://purl.obolibrary.org/obo/CL_0000956

A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein. [ http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/16551251 GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/20839338 http://www.ncbi.nlm.nih.gov/pubmed/18432934 GOC:dsd GOC:rhs http://www.ncbi.nlm.nih.gov/pubmed/9785673 ]

Synonyms: pre-BI cell

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Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive.

has related synonym

pro-B cell (Philadelphia nomenclature)

Term relations

Equivalent to:

precursor B cell and has part some V(D)J recombination-activating protein 1 and has part some V(D)J recombination-activating protein 2 and has part some DNA nucleotidylexotransferase and participates_in some immunoglobulin heavy chain V-D-J recombination and has plasma membrane part some CD34 molecule and has plasma membrane part some immunoglobulin iota chain and has plasma membrane part some immunoglobulin lambda-like polypeptide 1

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