early pro-B cell
http://purl.obolibrary.org/obo/CL_0002046
A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage. [ GOC:dsd GOC:tfm http://www.ncbi.nlm.nih.gov/pubmed/18432934 ]
Term info
Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
https://orcid.org/0000-0003-1980-3228
2010-04-28T11:19:11Z
Term relations
- pro-B cell and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some complement receptor type 2 and participates_in some immunoglobulin heavy chain V-D-J recombination and has plasma membrane part some pre-B cell receptor complex and has plasma membrane part some CD34 molecule and has plasma membrane part some B-cell receptor CD22 and has plasma membrane part some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 and has low plasma membrane amount some neprilysin
- pro-B cell
- has plasma membrane part some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- lacks_plasma_membrane_part some CD19 molecule
- lacks_plasma_membrane_part some complement receptor type 2
- participates_in some immunoglobulin heavy chain V-D-J recombination
- has plasma membrane part some pre-B cell receptor complex
- has low plasma membrane amount some neprilysin
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has plasma membrane part some B-cell receptor CD22
- has plasma membrane part some CD34 molecule