An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells. [ http://www.ncbi.nlm.nih.gov/pubmed/20683682 https://orcid.org/0000-0003-4183-8865 ]