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lymph node fibroblastic reticular cell

^ http://purl.obolibrary.org/obo/CL_0009102


A specialized, fibroblastic reticular cell of mesenchymal origin found in lymph nodes. In human, it expresses several markers common to myofibroblasts (desmin, vimentin, CD73, CD90, α-smooth muscle actin (αSMA)), and can be differentiated from endothelial cells by its lack of CD31 expression. These cells are critical for the overall organization and function of the lymph node. Lymph node fibroblastic reticular cells (FRCs) can be further classified based on their location, function, and unique marker expression. [ http://www.ncbi.nlm.nih.gov/pubmed/28262465 http://www.ncbi.nlm.nih.gov/pubmed/34256989 http://www.ncbi.nlm.nih.gov/pubmed/25998961 http://www.ncbi.nlm.nih.gov/pubmed/22566825 http://www.ncbi.nlm.nih.gov/pubmed/29752062 https://orcid.org/0000-0001-7655-4833 http://www.ncbi.nlm.nih.gov/pubmed/21435450 ]

Term info

contributor

https://orcid.org/0000-0002-2825-0621

date

2022-03-21T15:24:01Z

has broad synonym

fibroblastic reticular cell

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606

see also

https://github.com/obophenotype/cell-ontology/issues/1472

Term relations