protein serine/threonine kinase activity

http://purl.obolibrary.org/obo/GO_0004674

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [ GOC:bf http://www.ncbi.nlm.nih.gov/pubmed/2956925 ]

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Term history

Term info

database cross reference

Reactome:R-HSA-199298 (AKT phosphorylates CREB1)
Reactome:R-HSA-6805059 (CK2:FACT phosphorylates TP53)
Reactome:R-HSA-3239014 (MAPKAPK5 phosphorylates TP53)
Reactome:R-HSA-450499 (Protein Kinase B (AKT) phosphorylates KSRP)
Reactome:R-HSA-165692 (Phosphorylation of 4E-BP1 by activated mTORC1)
Reactome:R-HSA-3222006 (STK11 (LKB1) phosphorylates NUAK1)
Reactome:R-HSA-1358791 (Phosphorylation of USP8 by P-AKT)
Reactome:R-HSA-8942836 (CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6)
Reactome:R-HSA-419087 (LIM kinase phosphorylation by ROCK)
Reactome:R-HSA-193705 (IKKbeta phosphorylates IkB causing NF-kB to dissociate)
Reactome:R-HSA-6804955 (ATM phosphorylates MDM2)
Reactome:R-HSA-5683801 (CHEK2 phosphorylates BRCA1)
Reactome:R-HSA-3928608 (LIMK phosphorylates CFL1, inactivating it)
Reactome:R-HSA-448948 (Phosphorylation of E proteins by p38 MAPK)
Reactome:R-HSA-3769394 (AKT phosphorylates CBY1)
Reactome:R-HSA-198609 (AKT phosphorylates TSC2, inhibiting it)
Reactome:R-HSA-9626880 (MAPK11 or MAPK14 phosphorylates NCF1 at Ser345)
Reactome:R-HSA-975853 (Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR)
Reactome:R-HSA-5672948 (MARK3 phosphorylates KSR1)
Reactome:R-HSA-975170 (IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9)
Reactome:R-HSA-188350 (CAK-mediated phosphorylation of Cyclin E:Cdk2)
Reactome:R-HSA-3229152 (MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1))
Reactome:R-HSA-5624473 (Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit)
Reactome:R-HSA-2243938 (AKT1 E17K mutant is phosphorylated by TORC2 complex)
Reactome:R-HSA-200421 (Activation of cytosolic AMPK by phosphorylation)
Reactome:R-HSA-77071 (Phosphorylation (Ser5) of RNA pol II CTD)
Reactome:R-HSA-6798372 (ATM phosphorylates DYRK2)
Reactome:R-HSA-2466068 (Phosphorylation of cohesin by PLK1 at chromosomal arms)
Reactome:R-HSA-109702 (PDPK1 phosphorylates AKT2)
Reactome:R-HSA-2730868 (Phosphorylation of MEK7 by MEKK1)
Reactome:R-HSA-9673346 (Unknown kinase phosphorylates p-DVL)
Reactome:R-HSA-428961 (Phosphorylation of cPLA2 by MAPK p38 alpha)
Reactome:R-HSA-167084 (Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex)
Reactome:R-HSA-5632672 (ADRBK1 phosphorylates SMO dimer)
Reactome:R-HSA-3928577 (ROCK phosphorylates LIMK1,2)
Reactome:R-HSA-349455 (Phosphorylation of MDM4 by ATM)
Reactome:R-HSA-3229102 (p-MAPKAPK3 phosphorylates BMI1)
Reactome:R-HSA-69891 (Phosphorylation and activation of CHEK2 by ATM)
Reactome:R-HSA-211164 (AKT phosphorylates FOXO1A)
Reactome:R-HSA-8868340 (CDK5:p25 phosphorylates lamin B1)
Reactome:R-HSA-9604328 (AKT1 phosphorylates NOTCH4)
Reactome:R-HSA-3132737 (MAPKs phosphorylate ETS1 and ETS2)
Reactome:R-HSA-419083 (Myosin phosphatase inactivation by ROCK)
Reactome:R-HSA-6802973 (PLK3 phosphorylates CDC25C)
Reactome:R-HSA-5218906 (RIPK3 phosphorylates MLKL)
Reactome:R-HSA-2028629 (Phosphorylation of MOB1A and B by p-STK4 (p-MST1))
Reactome:R-HSA-3928616 (Activated ROCK phosphorylates MRLCs)
Reactome:R-HSA-2529020 (CK2 phosphorylates condensin I subunits)
Reactome:R-HSA-1168635 (PRKCB (PKC-beta) phosphorylates CARMA1)
Reactome:R-HSA-8876446 (p-ULK1 phosphorylates DENND3)
Reactome:R-HSA-9634702 (LINC01139 promotes phosphorylation of HIF1A by LRRK2)
Reactome:R-HSA-5675194 (Activated MAPK phosphorylates RAF1)
Reactome:R-HSA-5687086 (PAK1,2,3 phosphorylates MAPK6,4)
Reactome:R-HSA-168053 (Phosphorylated MAPKs phosphorylate ATF-2)
Reactome:R-HSA-6801666 (PLK2 phosphorylates CENPJ)
Reactome:R-HSA-9022314 (HIPK2 phosphorylates MECP2)
Reactome:R-HSA-5610718 (CK1 phosphorylates p-GLI2)
Reactome:R-HSA-9694293 (GSK3B phosphorylates Ncap)
Reactome:R-HSA-166284 (Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP)
Reactome:R-HSA-8863014 (p25-bound CDK5 phosphorylates CDC25A)
Reactome:R-HSA-75028 (Phosphorylation of Wee1 kinase by Chk1)
Reactome:R-HSA-9694620 (GSK3 phosphorylates N)
Reactome:R-HSA-198669 (p38MAPK phosphorylates MSK1)
Reactome:R-HSA-400382 (CSNK1E,CSNK1D phosphorylate CRY and PER proteins)
Reactome:R-HSA-399950 (Phosphorylation of cofilin by LIMK-1)
Reactome:R-HSA-5666160 (AURKB phosphorylates DIAPH2-2 at kinetochores)
Reactome:R-HSA-442724 (Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs))
Reactome:R-HSA-198746 (ERK1/2/5 activate RSK1/2/3)
Reactome:R-HSA-1181355 (Phosphorylation of R-SMAD2/3 by NODAL receptor)
Reactome:R-HSA-201691 (Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI)
Reactome:R-HSA-75010 (Phosphorylation of Cdc25C at Ser 216 by Chk1)
Reactome:R-HSA-75809 (Phosphorylation of Cdc25C at Ser216 by CHEK2)
Reactome:R-HSA-5672828 (mTORC1 phosphorylates AKT1S1)
Reactome:R-HSA-170977 (FRS2 is phosphorylated by active TrkA receptor)
Reactome:R-HSA-5635842 (ULK3 phosphorylates GLI)
Reactome:R-HSA-9656214 (MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants)
Reactome:R-HSA-3249371 (TBK1 phosphorylates STAT6 at Ser407)
Reactome:R-HSA-69604 (Phosphorylation of Cdc25A at Ser-123 by Chk1)
Reactome:R-HSA-5693549 (ATM phosphorylates histone H2AFX on S139 at DNA DSBs)
Reactome:R-HSA-8952289 (FAM20C phosphorylates FAM20C substrates)
Reactome:R-HSA-5668545 (NIK autophosphorylates on T559)
Reactome:R-HSA-8948146 (FUNDC1 is phosphorylated by ULK1 at Ser17)
Reactome:R-HSA-199863 (AKT can phosphorylate NR4A1 (NUR77))
Reactome:R-HSA-199935 (MSK1 activates CREB)
Reactome:R-HSA-5684096 (CDK2 phosphorylates RBBP8)
Reactome:R-HSA-9008822 (PPM1D dephosphorylates RUNX2)
Reactome:R-HSA-201717 (CSNK2-mediated phosphorylation of DVL)
Reactome:R-HSA-5674496 (Activated MAPKs phosphorylate MAP2K1)
Reactome:R-HSA-2029454 (Autophosphorylation of PAK1)
Reactome:R-HSA-195283 (Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3)
Reactome:R-HSA-9652165 (MAP2K mutants constitutively phosphorylate MAPKs)
Reactome:R-HSA-199839 (AKT can phosphorylate RSK)
Reactome:R-HSA-166245 (Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex)
Reactome:R-HSA-936951 (Activation of TAK1 complex bound to activated TLR4 complex)
Reactome:R-HSA-6805103 (AURKA phosphorylates TP53)
Reactome:R-HSA-6802943 (RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks)
Reactome:R-HSA-6800490 (ATM phosphorylates PIDD1)
Reactome:R-HSA-5682983 (ATM phosphorylates WHSC1)
Reactome:R-HSA-198611 (AKT phosphorylates IKKalpha)
Reactome:R-HSA-198599 (AKT phosphorylates MDM2)
Reactome:R-HSA-8933446 (Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling)
Reactome:R-HSA-5228811 (NFKBIA variant is not phosphorylated within IkBA:NF-kappaB)
Reactome:R-HSA-8863007 (p25-bound CDK5 phosphorylates CDC25B)
Reactome:R-HSA-8868118 (MAPK12 phosphorylates PTPN3)
Reactome:R-HSA-4332358 (Dissociation of CaM and CAMK2 autophosphorylation)
Reactome:R-HSA-162657 (Inactivation of Myt1 kinase)
Reactome:R-HSA-170076 (CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes)
Reactome:R-HSA-8854908 (PKA phosphorylates RET:GDNF:GFRA dimer)
Reactome:R-HSA-2243942 (PDPK1 phosphorylates AKT1 E17K mutant)
Reactome:R-HSA-399951 (Phosphorylation of CRMPs by GSK3beta)
Reactome:R-HSA-162363 (p-T309,S474-AKT2:PIP3 phosphorylates PDE3B)
Reactome:R-HSA-195300 (Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3)
Reactome:R-HSA-195318 (Phosphorylation of beta-catenin at Ser45 by CK1 alpha)
Reactome:R-HSA-8856813 (AAK1 phosphorylates AP-2 mu subunit at T156)
Reactome:R-HSA-5693609 (ATM phosphorylates TP53 at S15)
Reactome:R-HSA-445072 (Interaction of PAK1 with Rac1-GTP)
Reactome:R-HSA-198621 (AKT phosphorylates caspase-9)
Reactome:R-HSA-2399966 (AKT1 E17K mutant phosphorylates GSK3)
Reactome:R-HSA-5687183 (PRKDC phosphorylates DCLRE1C at DNA DSBs)
Reactome:R-HSA-1168641 (TAK1 associated with the CBM complex phosphorylates IKKbeta)
Reactome:R-HSA-5693575 (DNA-PKcs autophosphorylates)
Reactome:R-HSA-165162 (Phosphorylation of TSC2 by PKB)
Reactome:R-HSA-3228469 (MAP3K5 phosphorylates MKK3 and MKK6)
Reactome:R-HSA-9624526 (AKT phosphorylates FOXO3 downstream of ESR1 and EGFR)
Reactome:R-HSA-8863895 (IKKB phosphorylates SNAP23)
Reactome:R-HSA-1458463 (p-AKT2 phosphorylates RGC2)
Reactome:R-HSA-9681627 (GSK3 phosphorylates N)
Reactome:R-HSA-2399992 (AKT1 E17K mutant phosphorylates forkhead box transcription factors)
Reactome:R-HSA-5607732 (K63polyUb-TAK1 autophosphorylates)
Reactome:R-HSA-381091 (IRE1 dimer autophosphorylates)
Reactome:R-HSA-69608 (Phosphorylation of Cdc25A at Ser-123 by Chk2)
Reactome:R-HSA-176116 (Recruitment and activation of Chk1)
Reactome:R-HSA-2399999 (AKT1 E17K mutant phosphorylates RSK)
Reactome:R-HSA-1181156 (Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL)
Reactome:R-HSA-2730876 (Phosphorylation of IKK-beta by TAK1)
Reactome:R-HSA-9633008 (p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1)
Reactome:R-HSA-9032751 (Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3)
Reactome:R-HSA-5632670 (CSNK1A1 phosphorylates SMO dimer)
Reactome:R-HSA-450325 (c-FOS activation by phospho ERK1/2)
Reactome:R-HSA-112342 (Inactivation of MAP2K1 by CDK1)
Reactome:R-HSA-139918 (Phosphorylation of BIM by JNK)
Reactome:R-HSA-5692775 (SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs)
Reactome:R-HSA-5683792 (p-T68-CHEK2 autophosphorylates)
Reactome:R-HSA-2730900 (Activation of TAK1 complex bound to pUb-TRAF6)
Reactome:R-HSA-5607726 (Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB)
Reactome:R-HSA-5692779 (p-S182 MAPKAPK5 phosphorylates FOXO1)
Reactome:R-HSA-5260201 (p-AKT2 phosphorylates C2CD5)
Reactome:R-HSA-2984226 (PLK1 phosphorylates NEK9)
Reactome:R-HSA-2400001 (AKT1 E17K mutant phosphorylates CHUK (IKKalpha))
Reactome:R-HSA-5668932 (PAK2 phosphorylates myosin regulatory light chain (MRLC))
Reactome:R-HSA-5627775 (Autophosphorylation of PAK1,2,3)
Reactome:R-HSA-9613530 (PRKAA2 phosphorylates PLINs)
Reactome:R-HSA-975861 (Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex)
Reactome:R-HSA-9619515 (AMPK phosphorylates MAPT)
Reactome:R-HSA-399939 (Autophosphorylation of PAK)
Reactome:R-HSA-9009208 (Activated ERKs phosphorylate RUNX2)
Reactome:R-HSA-170055 (Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes)
Reactome:R-HSA-3928625 (PAKs autophosphorylate)
Reactome:R-HSA-6799332 (ATR phosphorylates TP53)
Reactome:R-HSA-8853419 (TPX2 promotes AURKA autophosphorylation)
Reactome:R-HSA-5686704 (Activated ATM phosphorylates DCLRE1C)
Reactome:R-HSA-5082405 (Phosphorylation of HSF1 at Ser326 induces transactivation)
Reactome:R-HSA-3857329 (MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB)
Reactome:R-HSA-2399969 (AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1)
Reactome:R-HSA-9648089 (NEK6 and NEK7 phosphorylate EML4)
Reactome:R-HSA-451347 (Activation of JNK by DSCAM)
Reactome:R-HSA-195287 (Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3)
Reactome:R-HSA-8868573 (CDK5:p25 phosphorylates PRDX2)
Reactome:R-HSA-349444 (Phosphorylation of COP1 at Ser-387 by ATM)
Reactome:R-HSA-8948039 (FUNDC1 is phosphorylated by CK2)
Reactome:R-HSA-163418 (perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP)
Reactome:R-HSA-2214351 (PLK1 phosphorylates GORASP1)
Reactome:R-HSA-5218814 (PAK2 autophorylates)
Reactome:R-HSA-934559 (SPRY2 is phosphorylated by phosphorylated MNK1)
Reactome:R-HSA-3000327 (PLK1 phosphorylates BORA)
Reactome:R-HSA-8850945 (Casein kinase II phosphorylates PTEN)
Reactome:R-HSA-6802926 (Mutant RAS:p-RAF complexes phosphorylate MAP2Ks)
Reactome:R-HSA-2060328 (Phosphorylation of WWTR1 (TAZ) by LATS1)
Reactome:R-HSA-156673 (Regulation of KIF23 (MKLP1) by phosphorylation)
Reactome:R-HSA-193647 (IRAK is activated)
Reactome:R-HSA-5607742 (K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta)
Reactome:R-HSA-5672978 (RAF phosphorylates MAP2K dimer)
Reactome:R-HSA-1168638 (Activated IKK phosphorylates I-kappaB)
Reactome:R-HSA-451152 (MAP kinase p38 phosphorylates KSRP)
Reactome:R-HSA-6805479 (TP53RK phosphorylates TP53)
Reactome:R-HSA-6788392 (ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA)
Reactome:R-HSA-6810233 (CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter)
Reactome:R-HSA-8878054 (HIPK2 phosphorylates RUNX1)
Reactome:R-HSA-5685156 (ATR phosphorylates RPA2)
Reactome:R-HSA-9653503 (KRAS4B is phosphorylated on serine 181)
Reactome:R-HSA-199895 (RSK1/2/3 phosphorylates CREB at Serine 133)
Reactome:R-HSA-6805399 (TAF1 phosphorylates TP53)
Reactome:R-HSA-399978 (Protein kinase C, alpha type phosphorylates MARCKS)
Reactome:R-HSA-9023132 (AURKB phosphorylates MECP2 at S423)
Reactome:R-HSA-5213466 (RIPK3 is phosphorylated)
Reactome:R-HSA-6795460 (SGK1 phosphorylates MDM2)
Reactome:R-HSA-199299 (AKT phosphorylates FOXO transcription factors)
Reactome:R-HSA-8853444 (AURKA phosphorylates PHLDA1)
Reactome:R-HSA-374696 (Phosphorylation of L1 by p90rsk)
Reactome:R-HSA-5672010 (Active MTORC1 phosphorylates ULK1)
Reactome:R-HSA-5685242 (CHEK1 phosphorylates BRCA2)
Reactome:R-HSA-913996 (PKA/PKG phosphorylate Rap1GAP2)
Reactome:R-HSA-198270 (PDPK1 phosphorylates AKT at T308)
Reactome:R-HSA-174174 (Phosphorylation of the Emi1 DSGxxS degron by Plk1)
Reactome:R-HSA-5686578 (Activated ATM phosphorylates ABL1)
Reactome:R-HSA-9662823 (PLK2, MAPK14 phosphorylate ADAM17)
Reactome:R-HSA-5682026 (MRN bound to shortened telomeres activates ATM)
Reactome:R-HSA-9012319 (p-TEFb phosphorylates serine 2 in RNA polymerase II CTD)
Reactome:R-HSA-5692768 (MAPKAPK5 phosphorylates KALRN)
Reactome:R-HSA-5082387 (Phosphorylation of HSF1 at Ser230 induces transactivation)
Reactome:R-HSA-5669250 (PAK1 phosphorylates FLNA)
Reactome:R-HSA-399952 (Phosphorylation of LIMK-1 by PAK)
Reactome:R-HSA-9648888 (p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha))
Reactome:R-HSA-8868344 (CDK5:p25 phosphorylates lamin A)
Reactome:R-HSA-9008480 (GSK3B phosphorylates RUNX2)
Reactome:R-HSA-8877691 (MAP2K6 phosphorylates PIP4K2B)
Reactome:R-HSA-168140 (Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex)
Reactome:R-HSA-9007539 (CHEK1 phosphorylates E2F6)
Reactome:R-HSA-3209160 (Activated ERKs phosphorylate ERF)
Reactome:R-HSA-198347 (AKT phosphorylates BAD)
Reactome:R-HSA-111919 (PKA phosphorylates CREB1)
Reactome:R-HSA-349426 (Phosphorylation of MDM4 by CHEK2)
Reactome:R-HSA-6798374 (DYRK2 phosphorylates TP53)
Reactome:R-HSA-5668984 (PAK1 or PAK2 phosphorylates MYLK)
Reactome:R-HSA-202437 (Phosphorylation of CARMA1)
Reactome:R-HSA-156678 (Activation of Cdc25C)
Reactome:R-HSA-166286 (Multiple IRAK1 autophosphorylation steps)
Reactome:R-HSA-5693551 (Phosphorylation of BRCA1-A complex at multiple sites by ATM)
Reactome:R-HSA-165766 (Phosphorylation and activation of eIF4G by activated S6K1)
Reactome:R-HSA-5218854 (p-Y420-FYN is phosphorylated on S21)
Reactome:R-HSA-3371531 (Constitutive phosphorylation by pERK1/2)
Reactome:R-HSA-5693598 (ATM phosphorylates NBN)
Reactome:R-HSA-170087 (CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes)
Reactome:R-HSA-937022 (IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP)
Reactome:R-HSA-163416 (hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP)
Reactome:R-HSA-8878050 (HIPK2 phosphorylates RUNX1 and EP300)
Reactome:R-HSA-2028673 (Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N)
Reactome:R-HSA-156682 (PLK1 phosphorylates NUDC)
Reactome:R-HSA-109822 (MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1)
Reactome:R-HSA-389756 (AKT interacts and phosphorylates Cot)
Reactome:R-HSA-5682101 (PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer)
Reactome:R-HSA-8863011 (p25-bound CDK5 phosphorylates CDC25C)
Reactome:R-HSA-3928640 (PAKs phosphorylate MLC)
Reactome:R-HSA-9612509 (SGK phosphorylates SRF)
Reactome:R-HSA-450474 (MK2 phosphorylates BRF1)
Reactome:R-HSA-5624492 (PAK phosphorylates p21 RAF1 on S338)
Reactome:R-HSA-2730896 (Phosphorylation of MEK4 by MEKK1)
Reactome:R-HSA-1454699 (AMPK-alpha2 phosphorylates TBC1D1)
Reactome:R-HSA-6802911 (High kinase activity BRAF complexes phosphorylate MAP2Ks)
Reactome:R-HSA-6802935 (MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers)
Reactome:R-HSA-975865 (IRAK4 autophosphorylation within the complex activated TLR:MyD88)
Reactome:R-HSA-3857328 (RPS6KA1/2/3 phosphorylates CEBPB on S321)
Reactome:R-HSA-109860 (MAP2K1 phosphorylates MAPK3)
Reactome:R-HSA-5687101 (p-T182 MAPKAPK5 phosphorylates FOXO3)
Reactome:R-HSA-2294580 (PLK1 hyperphosphorylates Condensin II complex)
Reactome:R-HSA-3858480 (WNT-dependent phosphorylation of DVL)
Reactome:R-HSA-198613 (AKT phosphorylates p21Cip1 and p27Kip1)
Reactome:R-HSA-176298 (Activation of claspin)
Reactome:R-HSA-975160 (Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9)
Reactome:R-HSA-1445144 (p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4))
Reactome:R-HSA-170126 (Phosphorylation of Cyclin B1 in the CRS domain)
Reactome:R-HSA-2028583 (Phosphorylation of YAP by LATS2)
Reactome:R-HSA-211583 (Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197)
Reactome:R-HSA-975125 (Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9)
Reactome:R-HSA-8944454 (mTORC1 phosphorylates MAF1)
Reactome:R-HSA-199917 (MAPKAPK2 phosphorylates CREB at Serine 133)
Reactome:R-HSA-9612501 (SGK phosphorylates CREB1)
Reactome:R-HSA-2028661 (Phosphorylation of WWTR1 (TAZ) by LATS2)
Reactome:R-HSA-5683964 (ATM phosphorylates EYA1-4)
Reactome:R-HSA-6805285 (PLK3 phosphorylates TP53)
Reactome:R-HSA-429714 (monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP)
Reactome:R-HSA-8852306 (Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends)
Reactome:R-HSA-165182 (Phosphorylation of complexed TSC2 by PKB)
Reactome:R-HSA-2176475 (Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9)
Reactome:R-HSA-450222 (Active p38 MAPK phosphorylates MAPKAPK2 or 3)
Reactome:R-HSA-975134 (Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9)
Reactome:R-HSA-202459 (Phosphorylation of Bcl10)
Reactome:R-HSA-202541 (p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB)
Reactome:R-HSA-5679205 (ULK1 phosphorylates Beclin-1)
Reactome:R-HSA-975180 (First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9)
Reactome:R-HSA-5610732 (GSK3 phosphorylates p-GLI3)
Reactome:R-HSA-3371567 (DBC1 is phosphorylated by ATM/ART)
Reactome:R-HSA-377186 (Activated Akt1 phosphorylates AKT1S1 (PRAS40))
Reactome:R-HSA-2028591 (Phosphorylation of STK3 (MST2) and SAV1 by STK3)
Reactome:R-HSA-3239019 (Active p38 MAPK phosphorylates MAPKAPK5)
Reactome:R-HSA-8873929 (Casein kinase II phosphorylates STARD10)
Reactome:R-HSA-9648883 (p-T-EIF2AK1:ferriheme dimer autophosphorylates)
Reactome:R-HSA-419197 (Myosin regulatory light chain phosphorylation by ROCK)
Reactome:R-HSA-2168079 (MASTL (GWL) phosphorylates ARPP19)
Reactome:R-HSA-9612980 (BRAF in Rap1-GTP complex:BRAF complex autophosphorylates)
Reactome:R-HSA-8868666 (CDK5:p25 phosphorylates JUN)
Reactome:R-HSA-5682598 (ATM phosphorylates HERC2)
Reactome:R-HSA-1181149 (ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin)
Reactome:R-HSA-198731 (ERK1/2 activates ELK1)
Reactome:R-HSA-164151 (LKB1 phosphorylates the alpha subunit of AMPK heterotrimer)
Reactome:R-HSA-6802933 (p-BRAF and RAF fusion dimers phosphorylate MAP2Ks)
Reactome:R-HSA-6805785 (AKT phosphorylates PHF20)
Reactome:R-HSA-5213464 (RIPK1 is phosphorylated)
Reactome:R-HSA-166119 (First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal)
Reactome:R-HSA-8939963 (Activated AKT phosphorylates RUNX2)
Reactome:R-HSA-8948757 (AKT phosphorylates MKRN1)
Reactome:R-HSA-3000310 (AURKA phosphorylates PLK1)
Reactome:R-HSA-399944 (Phosphorylation of CRMPs by Cdk5)
Reactome:R-HSA-5672973 (MAP2Ks phosphorylate MAPKs)
Reactome:R-HSA-156699 (Inactivation of Wee1 kinase)
Reactome:R-HSA-5229343 (AXIN is phosphorylated in the destruction complex)
Reactome:R-HSA-201677 (Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta)
Reactome:R-HSA-419644 (Transphosphorylation of pLIMK1)
Reactome:R-HSA-975878 (First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR)
Reactome:R-HSA-5685230 (CHEK1 phosphorylates RAD51)
Reactome:R-HSA-2399996 (AKT1 E17K mutant phosphorylates CREB1)
Reactome:R-HSA-918229 (Phosphorylation and release of IRF3/IRF7)
Reactome:R-HSA-450490 (Protein Kinase B/Akt phosphorylates BRF1)
Reactome:R-HSA-198756 (ERK1/2 phosphorylates MSK1)
Reactome:R-HSA-1362270 (Phosphorylation of LIN52 component of MuvB by DYRK1A)
Reactome:R-HSA-5668947 (PAK1 phosphorylates myosin phosphatase)
Reactome:R-HSA-8852317 (PLK1 phosphorylates GTSE1)
Reactome:R-HSA-975874 (Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex)
Reactome:R-HSA-9610156 (MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF)
Reactome:R-HSA-2029460 (PAK1 phosphorylates LIMK1)
Reactome:R-HSA-5578777 (DMPK phosphorylates PLN)
Reactome:R-HSA-5218821 (PDK1 phosphorylates PKC)
Reactome:R-HSA-5684887 (Activation of CHEK1 at resected DNA DSBs)
Reactome:R-HSA-2399981 (AKT1 E17K mutant phosphorylates MDM2)
Reactome:R-HSA-5218916 (p-MAPK2/3 phosphorylates HSP27)
Reactome:R-HSA-4332388 (Activation of MAP3K7 in response to WNT)
Reactome:R-HSA-5690250 (p-T182-MAPKAPK5 phoshphorylates DNAJB1)
Reactome:R-HSA-5357472 (PAK1-3 autophosphorylates)
Reactome:R-HSA-2730856 (Autophosphorylation of PAK)
Reactome:R-HSA-163010 (Down Regulation of Emi1 through Phosphorylation of Emi1)
Reactome:R-HSA-3928620 (PAK1 autophosphorylates)
Reactome:R-HSA-450827 (hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2.)
Reactome:R-HSA-202222 (Phosphorylation of PKC theta)
Reactome:R-HSA-6795290 (TORC2 complex phosphorylates SGK1)
Reactome:R-HSA-8940100 (CDK1 phosphorylates VCPIP1)
Reactome:R-HSA-6805126 (AURKB phosphorylates TP53)
Reactome:R-HSA-112381 (Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex)
Reactome:R-HSA-9699579 (AKT phosphorylates FOXO3 downstream of FLT3)
Reactome:R-HSA-165718 (mTORC1 phosphorylation of RPS6KB1 (S6K))
Reactome:R-HSA-195275 (Phosphorylation of APC component of the destruction complex)
Reactome:R-HSA-167098 (Phosphorylation (Ser5) of RNA pol II CTD)
Reactome:R-HSA-6799246 (CHEK1 phosphorylates TP53)
Reactome:R-HSA-198371 (AKT phosphorylates GSK3)
Reactome:R-HSA-912470 (ATR phosphorylates Histone H2A.X at unsynapsed regions)
Reactome:R-HSA-2396007 (IRF3 is phosphorylated by TBK1)
Reactome:R-HSA-209087 (IKBA is phosphorylated by Phospho IKKB kinase)
Reactome:R-HSA-5607722 (Active NIK phosphorylates IKKA dimer)
Reactome:R-HSA-4411402 (Activation of NLK)
Reactome:R-HSA-2028670 (Phosphorylation of MOB1A and B by p-STK4(MST1)/N)
Reactome:R-HSA-199910 (MSK1 activates ATF1)
Reactome:R-HSA-5357477 (PAK1-3 phosphorylates VE-cadherin)
Reactome:R-HSA-9645535 (ALPK1 phosphorylates TIFA)
Reactome:R-HSA-432110 (Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding)
Reactome:R-HSA-5610722 (CK1 phosphorylates p-GLI3)
Reactome:R-HSA-165758 (Phosphorylation and inactivation of eEF2K by activated S6K1)
Reactome:R-HSA-4332363 (Autophosphorylation and activation of CAMK2)
Reactome:R-HSA-9683664 (GSK3B phosphorylates Ncap)
Reactome:R-HSA-5218826 (Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732)
Reactome:R-HSA-5693536 (ATM phosphorylates MDC1)
Reactome:R-HSA-156723 (Regulation of KIF20A (MKL2) by phosphorylation)
Reactome:R-HSA-9632868 (CDKN1B is phosphorylated in response to estrogen)
Reactome:R-HSA-198640 (TORC2 (mTOR) phosphorylates AKT at S473)
Reactome:R-HSA-2399985 (AKT1 E17K mutant phosphorylates caspase-9)
Reactome:R-HSA-5671763 (p-T774-PKN1 phosphorylates PPP1R14A)
Reactome:R-HSA-3222020 (NUAK1 phosphorylates TP53)
Reactome:R-HSA-2028635 (Phosphorylation of MOB1A and B by p-STK3 (p-MST2))
Reactome:R-HSA-429016 (ALOX5 is phosphorylated by MAPKAP2)
Reactome:R-HSA-4411383 (NLK phosphorylates TCF/LEF)
Reactome:R-HSA-2984258 (NEK9 phosphorylates NEK6/NEK7)
Reactome:R-HSA-446694 (IRAK4 phosphorylates IRAK1)
Reactome:R-HSA-4551570 (VANGL2 is phosphorylated in response to WNT5A)
Reactome:R-HSA-9610153 (Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF)
Reactome:R-HSA-5675868 (ULK1 phosphorylates ATG13 and RB1CC1)
Reactome:R-HSA-6801675 (PLK2 phosphorylates NPM1)
Reactome:R-HSA-4608825 (DVL2 is phosphorylated after WNT5A binding to FZD)
Reactome:R-HSA-139908 (Phosphorylation of DLC2 by MAPK8)
Reactome:R-HSA-5665868 (AMPK (complex) phosphorylates ULK1 (complex))
Reactome:R-HSA-9032863 (CDK5 phosphorylates NTRK2)
Reactome:R-HSA-2029469 (p-ERK phosphorylates WAVEs and ABI)
Reactome:R-HSA-199929 (ERK5 activates the transcription factor MEF2)
Reactome:R-HSA-1632857 (ULK1 phosphorylates AMBRA1:BECN1 complex)
Reactome:R-HSA-2574840 (AJUBA facilitates AURKA autophosphorylation)
Reactome:R-HSA-6805276 (CDK5 phosphorylates TP53)
Reactome:R-HSA-2470508 (ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin)
Reactome:R-HSA-6811454 (MAPKs phosphorylate PP2A)
Reactome:R-HSA-9619843 (ERKs phosphorylate RSKs)
Reactome:R-HSA-2562526 (PLK1 phosphorylates OPTN)
Reactome:R-HSA-2028679 (Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N)
Reactome:R-HSA-2430535 (MASTL phosphorylates ENSA)
Reactome:R-HSA-5694441 (CSNK1D phosphorylates SEC23)
Reactome:R-HSA-3772435 (WNT signaling stimulates CSNK1-dependent phosphorylation of DVL)
Reactome:R-HSA-9620004 (RSKs autophosphorylate)
Reactome:R-HSA-202510 (Activation of TAK1-TAB2 complex)
Reactome:R-HSA-6804266 (CHEK2 phosphorylates TTC5)
Reactome:R-HSA-5357831 (CYLD is phosphorylated by IKK)
Reactome:R-HSA-1638803 (Phosphorylation of cohesin by PLK1 at centromeres)
Reactome:R-HSA-2993898 (VRK1/VRK2 phosphorylate BANF1)
Reactome:R-HSA-450463 (MK2 phosphorylates ZFP36 (Tristetraproline, TTP))
Reactome:R-HSA-2399941 (AKT1 E17K mutant phosphorylates BAD)
Reactome:R-HSA-165777 (Phosphorylation and activation of eIF4B by activated S6K1)
Reactome:R-HSA-2399982 (AKT1 E17K mutant phosphorylates TSC2, inhibiting it)
Reactome:R-HSA-187688 (p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3)
Reactome:R-HSA-6795473 (PDPK1 phosphorylates SGK1)
Reactome:R-HSA-109823 (MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2)
Reactome:R-HSA-1592233 (p38 MAPK phosphorylates PPARGC1A)
Reactome:R-HSA-2028589 (Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2))
Reactome:R-HSA-4088134 (PLK1 phosphorylates FOXM1)
Reactome:R-HSA-5687094 (p-S MAPK6,4 phosphorylate MAPKAPK5)
Reactome:R-HSA-6814409 (CK2 phosphorylates PDCL)
Reactome:R-HSA-2399977 (AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40))
Reactome:R-HSA-5675198 (Activated MAPKs phosphorylate BRAF)
Reactome:R-HSA-75820 (Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta)
Reactome:R-HSA-5671919 (Activated CIT phosphorylates MRLCs)
Reactome:R-HSA-165726 (Phosphorylation of Ribosomal protein S6 by activated S6K1)
Reactome:R-HSA-9656215 (RAF1 mutant complexes phosphorylate MAP2K dimer)
Reactome:R-HSA-2422927 (MAPK3-3 or MAPK1 phosphorylate GORASP2)
Reactome:R-HSA-174119 (Free APC/C phosphorylated by Plk1)
Reactome:R-HSA-6804276 (ATM phosphorylates TTC5)
EC:2.7.11.1 (skos:narrowMatch)
Reactome:R-HSA-6799097 (ATM phosphorylates ZNF420)
Reactome:R-HSA-5684140 (ATM phosphorylates RBBP8)
Reactome:R-HSA-5687090 (p-S MAPK6 phosphorylates NCOA3)
Reactome:R-HSA-211650 (Autophosphorylation of PAK-2p34 in the activation loop)
Reactome:R-HSA-937059 (Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex)
Reactome:R-HSA-69685 (CHEK2 phosphorylates TP53)
Reactome:R-HSA-381111 (EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK)
Reactome:R-HSA-5610730 (GSK3 phosphorylates p-GLI2)
Reactome:R-HSA-2028675 (Phosphorylation of MOB1A and B by p-STK3(MST2)/N)
Reactome:R-HSA-200143 (AKT phosphorylates AKT1S1 (PRAS40))
Reactome:R-HSA-8870558 (CDK5:p25 phosphorylates FOXO3)
Reactome:R-HSA-446701 (IRAK4-activated IRAK1 autophosphorylates)
Reactome:R-HSA-6805640 (AKT phosphorylates KAT6A)
Reactome:R-HSA-2399988 (AKT1 E17K mutant phosphorylates NR4A1 (NUR77))
Reactome:R-HSA-933525 (Phosphorylation and release of IRF7)
Reactome:R-HSA-4793911 (MAPKAPK2 phosphorylates HSF1)
Reactome:R-HSA-8868567 (CDK5:p25 phosphorylates PRDX1)
Reactome:R-HSA-2028555 (Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1))
Reactome:R-HSA-5687121 (p-S MAPKAPK5 phosphorylates HSPB1)
Reactome:R-HSA-202500 (Activation of IKK complex)
Reactome:R-HSA-9633742 (EIF2AK4 (GCN2) dimer autophosphorylates)
Reactome:R-HSA-442832 (PAK phosphorylates cortactin)
Reactome:R-HSA-8868260 (CDK5:p25 phosphorylates GOLGA2)
Reactome:R-HSA-3371435 (Constitutive phosphorylation by GSK3)
Reactome:R-HSA-2028284 (Phosphorylation of STK4 (MST1) and SAV1 by STK4)
Reactome:R-HSA-6799409 (HIPK2 phosphorylates TP53)
Reactome:R-HSA-2028598 (Phosphorylation of YAP by LATS1)
Reactome:R-HSA-5683425 (ATM phosphorylates TP53BP1 at DNA DSBs)
Reactome:R-HSA-109862 (MAP2K2 phosphorylates MAPK1)
Reactome:R-HSA-170116 (Myt-1 mediated phosphorylation of Cyclin A:Cdc2)
Reactome:R-HSA-5693540 (MRN activates ATM)
Reactome:R-HSA-1225894 (Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL)
Reactome:R-HSA-380272 (Plk1-mediated phosphorylation of Nlp)
Reactome:R-HSA-448955 (Phosphorylation of MEF2 proteins by p38)
Reactome:R-HSA-9627089 (CASP9 is phosphorylated at T125)
Reactome:R-HSA-5672008 (Thr-180 of ULK1 is phosphorylated)
Reactome:R-HSA-2990880 (NEK6/NEK7 phosphorylates NUP98)
Reactome:R-HSA-1449597 (p-AKT2 phosphorylates Myosin 5A)
Reactome:R-HSA-1549526 (Phosphorylation of SMAD2/3 by Activin:Activin Receptor)
Reactome:R-HSA-111970 (PKC phosphorylates GRK2)
Reactome:R-HSA-392752 (Phosphorylation of L1 by CK-II)
Reactome:R-HSA-187949 (CAK-mediated phosphorylation of Cyclin A:Cdk2)
Reactome:R-HSA-442739 (PDPK1 phosphorylates RSKs)
Reactome:R-HSA-5635841 (GLI proteins are phosphorylated)
Reactome:R-HSA-6802919 (RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks)
Reactome:R-HSA-9610163 (BRAF autophosphorylates downstream of RAP1 and NGF)
Reactome:R-HSA-9013978 (Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex)

has related synonym

serine/threonine protein kinase activity, serine(threonine) protein kinase activity, protein serine-threonine kinase activity

has alternative id

GO:0004700, GO:0004696, GO:0004695, GO:0106311

has narrow synonym

threonine-specific protein kinase activity, protein kinase (phosphorylating) activity, protein-serine kinase activity, serine kinase activity, protein threonine kinase activity, protein serine kinase activity, serine protein kinase activity, serine-specific protein kinase activity, protein phosphokinase activity

has obo namespace

molecular_function

GO:0004674

term tracker item

https://github.com/geneontology/go-ontology/issues/20114