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cell death

^ http://purl.obolibrary.org/obo/GO_0008219


Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). [ GOC:mah http://www.ncbi.nlm.nih.gov/pubmed/25236395 GOC:mtg_apoptosis ]

Term info

Subsets

goslim_chembl, goslim_drosophila, goslim_agr, goslim_mouse, goslim_plant

comment

This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.

has related synonym

necrosis, accidental cell death

has obo namespace

biological_process

id

GO:0008219

imported from

http://purl.obolibrary.org/obo/cl.owl