tumor necrosis factor production
http://purl.obolibrary.org/obo/GO_0032640
The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. [ http://www.ncbi.nlm.nih.gov/pubmed/15560120 GOC:mah http://www.ncbi.nlm.nih.gov/pubmed/10891884 ]
Synonyms: TNF production, cachectin production
Term info
gocheck_do_not_annotate
Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms.
sl
2015-06-15T22:59:26Z
TNF-alpha production, Tnfa production, tumor necrosis factor-alpha production
GO:1990774, GO:0042533
tumor necrosis factor secretion, TNF alpha biosynthesis, tumor necrosis factor synthesis, TNF-alpha biosynthesis, TNF-alpha biosynthetic process, tumor necrosis factor biosynthetic process, TNF biosynthesis, tumor necrosis factor formation, TNF biosynthetic process, tumor necrosis factor biosynthesis, tumor necrosis factor anabolism
biological_process
GO:0032640