apoptotic signaling pathway

http://purl.obolibrary.org/obo/GO_0097190

The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. [ GOC:mtg_apoptosis ]

Synonyms: apoptotic signalling pathway, induction of apoptosis by extracellular signals

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This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.

created by

creation date

2011-11-23T09:30:23Z

has alternative id

GO:0008624

has obo namespace

biological_process

GO:0097190

imported from

http://purl.obolibrary.org/obo/cl.owl