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exocrine pancreas

^ http://purl.obolibrary.org/obo/UBERON_0000017

The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. [ GOC:GO http://orcid.org/0000-0002-6601-2165 ]

Synonyms: pars exocrina pancreatis, exocrine pancreas

Term info

database cross reference
Subsets

uberon_slim, pheno_slim, vertebrate_core, organ_slim, human_reference_atlas

UBPROP 0000001

The part of the pancreas that acts as an exocrine gland, consisting of the pancreatic acini, which produce pancreatic juice and secrete it into the intestine to aid in protein digestion. [TFD][VHOG], The exocrine pancreas is composed of acinar epithelial cells and ductal epithelium that manufacture the proteolytic enzymes and bicarbonate required for digestion.[TAO]

UBPROP 0000003

In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]

has related synonym

exocrine part of pancreas, exocrine component of pancreas

id

UBERON:0000017

prefLabel

Exocrine pancreas

present in taxon

http://purl.obolibrary.org/obo/NCBITaxon_9606