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crypt of Lieberkuhn

^ http://purl.obolibrary.org/obo/UBERON_0001983

The tubular intestinal glands found in the mucosal membranes. [ http://openisbn.com/search.php?q=0-683-40008-8&isbn=1/ https://github.com/obophenotype/uberon/issues/213 MP:0000490 ]

Synonyms: crypt of Lieberkühn, Lieberkühn crypt, Lieberkuhn crypt, Lieberkuhn's gland, Lieberkuhn gland, follicles of Lieberkühn, Lieberkuhn's glands, crypts of Lieberkühn, crypt of Lieberkuhn, intestinal crypt, intestinal crypts

Term info

database cross reference
Subsets

pheno_slim, organ_slim

plural term
crypts of Lieberkühn

plural term
intestinal crypts

plural term
Lieberkuhn's glands

UBPROP 0000001

In histology, an intestinal crypt, also crypt of LieberkC<hn and intestinal gland, is a gland found in the epithelial lining of the small intestine and colon. The crypts secrete various enzymes, including sucrase and maltase, along with endopeptidases and exopeptidases. Also new epithelium is formed here, keeping in mind that the epithelium at this site is frequently worn away by the passing food. Loss of proliferation control in the crypts is thought to lead to colorectal cancer. The basal portion of the Crypt contains multipotent stem cells. At each mitosis one daughter remains a stem cell while the other differentiates and migrates up the side of the crypt and eventually the villus. Goblet cells are among the cells produced in this fashion[Wikipedia:Intestinal_crypt].

UBPROP 0000008

Most fish lack intestinal glands that extend into the mucosa, Gadidae (Jacobshagen 1937) and Macrouridae (Geisterdoerfer 1973( have glands at the base of surface folds throughout intestine - these have been called crypts, but cell types are the same as for surface epithelium. Crypts have been described in salamander midguts (Reeder 1964) some reptiles (Luppa 1977) and some birds (Ziswiler and Farner 1972). Reptile crypts are less developed than birds and mammals, with epithelium similar to the surface. Avian crypts vary from those with absorprive and goblet cells to those that have cells with basophilic granules

depicted by

http://upload.wikimedia.org/wikipedia/commons/3/38/Small_intestine_low_mag.jpg

has related synonym

intestinal gland of Lieberkuhn

has broad synonym

intestinal gland

id

UBERON:0001983

prefLabel

Crypt of Lieberkuhn

see also

http://purl.obolibrary.org/obo/UBERON_2005256