cortical subplate
http://purl.obolibrary.org/obo/UBERON_0004035
The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate. [ MP:0008440 https://github.com/obophenotype/mouse-anatomy-ontology/issues/1 http://en.wikipedia.org/wiki/Subplate ]
Synonyms: subplate zone, subplate, cerebral cortex subplate
Term info
pheno_slim
The transient fetal subplate zone, together with the marginal zone and the cortical plate, represents the developmental anlage of the mammalian cerebral cortex. It serves as a waiting compartment for growing cortical afferents; its cells are involved in the establishment of pioneering cortical efferent projections and transient fetal circuitry, and apparently have a number of other developmental roles. The subplate zone is a phylogenetically recent structure and it is most developed in the human brain. Subplate neurons are among the first generated neurons in the mammalian cerebral cortex [1]. These neurons disappear during postnatal development and are important in establishing the correct wiring [2][3] and functional maturation [4] of the cerebral cortex. Subplate neurons appear to be selectively sensitive to injury (such as hypoxia) which in humans are associated with motor and cognitive defects
uberon
UBERON:0004035
Term relations
- layer of developing cerebral cortex and adjacent_to some cortical intermediate zone and adjacent_to some cortical plate
- layer of developing cerebral cortex
- adjacent_to some cortical plate
- develops from some cortical preplate
- adjacent_to some cortical intermediate zone