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apical ectodermal ridge

^ http://purl.obolibrary.org/obo/UBERON_0004356

Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. [ MP:0001676 http://en.wikipedia.org/wiki/Apical_ectodermal_ridge ]

Synonyms: apical epidermal ridge

Term info

database cross reference
Subsets

pheno_slim

UBPROP 0000001

Distal ectodermal thickening which forms along the anterior-posterior limb axis. Signaling from this region influences proximal-distal patterning of the limb. Structure is missing in some lineages (salamanders, Eleutherodactylus coqui) however morphologically their indistinct distal ectoderm may still be involved in signaling.[AAO], Proliferative region that is part of the developing fin fold or fin.[TAO]

UBPROP 0000002

relationship loss: subclass proliferative region (TAO:0000098)[TAO]

UBPROP 0000008

The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold

UBPROP 0000009

maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop

curator note

note that media, dorsal fins etc have AERs.

depicted by

http://upload.wikimedia.org/wikipedia/commons/5/56/Limbbuddiagram.jpg

has related synonym

AER, crista ectodermalis apicalis

id

UBERON:0004356