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Megaloblastic anemia

^ http://purl.obolibrary.org/obo/HP_0001889

Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts). [ HPO:probinson ]

Term info

database cross reference
  • SNOMEDCT_US:53165003
  • MSH:D000749
  • UMLS:C0002888
comment

Megaloblastic anemia can result from folic acid deficiency or vitamin B12 deficiency. Folate deficiency leads to an impairment of DNA synthesis such that the cell cycle cannot progress from the G2 growth stage to the mitosis stage, in turn leading to continuing cell growth without division, which presents as macrocytosis.

definition

Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts).

has alternative id

HP:0004858

has exact synonym

Megaloblastic anaemia

id

HP:0001889

Term relations

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