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Reduced factor XII activity

^ http://purl.obolibrary.org/obo/HP_0004841

Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade. [ HPO:probinson ]

Term info

database cross reference
  • SNOMEDCT_US:46981006
  • UMLS:C0015526
  • MSH:D005175
definition

Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade.

has alternative id

HP:0005551, HP:0008286, HP:0005514

has exact synonym

Factor XII deficiency, Hageman factor deficiency

id

HP:0004841

Term relations