Ph-positive acute lymphoblastic leukemia
http://purl.obolibrary.org/obo/HP_0004848
A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity. [ PMID:21472706 ]
Term info
- SNOMEDCT_US:425688002
- UMLS:C1960397
- SNOMEDCT_US:426955004
A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity.
Philadelphia-positive acute lymphoblastic leukaemia, Ph-positive acute lymphoblastic leukaemia, Philadelphia-positive acute lymphoblastic leukemia
HP:0004848